Acrocephaly causes

Acrocephaly, Negated. None. Unsure. None. Possible Causes. Sickle Cell Anemia. Sickle cell disease (sickle cell anemia, drepanocytosis) is an autosomal recessive blood disorder, characterized by sickle-shaped erythrocytes. Chronic anemia is present in all individuals with sickle cell disease Macrocephaly is usually a symptom of other conditions. Benign familial macrocephaly is an inherited condition. It happens in families predisposed to having larger heads. Sometimes there is a.. Some babies have microcephaly because of changes in their genes. Other causes of microcephaly, including severe microcephaly, can include the following exposures during pregnancy: Certain infections during pregnancy, such as rubella, toxoplasmosis, or cytomegalovirus Severe malnutrition, meaning a lack of nutrients or not getting enough foo Acrocephaly, or tower head, is the term applied to that syndrome consisting of a dome-shaped skull, with characteristic Roentgen-ray findings, exophthalmos and optic nerve changes, associated with some minor abnormalities, such as a high, arched palate and deformities of the hands or feet. Acrocephaly is synonymous with thurmschädel, Spitzkopf. Pathologic macrocephaly may be caused by congenital anatomic abnormalities, genetic conditions, or by environmental events

ACROCEPHALY. A disorder characterized by an exceptionally high skull and severe mental retardation. In one syndrome (Crouzon) these symptoms are associated with exophthalmos (protruding eyes), small orbital (eye) cavities, and increased intracranial pressure. This condition is believed to be due to a single dominant gene with varying. Primary care physicians may refer to the pediatric neurosurgeon based on your child's increasing head circumference Causes of macrocephaly include: Benign familial macrocephaly - other family members with big heads (inherited) Excess fluid in the brain - benign extra-axial fluid of infancy or hydrocephalu A common cause of MC and ICP in childhood is HC.Hydrocephalus is the state of excessive CSF volume withprogressive enlargement of the ventricles, subarachnoidspaces, or both.17Y20Hydrocephalus may be caused by animbalance between CSF production and absorption, by ablockage of CSF flow, or from alterations in ventricularcompliance and CSF pulse pressure.17,20Hydrocephalus du The early fusion of the skull causes the head to be cone-shaped (acrocephaly). This can also lead to a sunken appearance in the middle of the face (midface hypoplasia), wide-set eyes (hypertelorism), and a beaked nose. An underdeveloped upper jaw and shallow eye sockets can cause dental and vision problems

Acrocephaly: Causes & Reasons - Symptom

Acrocephaly (Oxycephaly): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis More often, repeated measurements of the head circumference over time are needed to confirm that the head circumference is increased and the problem is getting worse. Diagnostic tests that may be ordered include: Head CT scan. MRI of the head. Treatment depends on the cause of the increased head size. For example, for hydrocephalus, surgery may.

Macrocephaly: Causes, Symptoms, and Treatment

  1. ently enlarged cranial compo-nent: extraaxial spaces, ventricles, brain pa-renchyma, and skull (Table 1). Approach to Imaging of a Child With a Large Hea
  2. Craniostenosis affecting most commonly the coronal sutures which may lead to the development of acrocephaly, brachycephaly, flat occiput, and high forehead. Large and delayed closing of fontanelles. Gaping midline defect; Cloverleaf skull anomaly is present although this happens only in 4 percent of infants
  3. ant inheritance has been also proposed
  4. Causes and Risk factors Carpenter syndrome is a genetic condition, caused by a mutation (change) on a specific gene. Research has identified the affected genes as the RAB23 gene or MEGF8 gene. Both these genes affect how certain cells in the body - including bone cells - grow, divide and die
  5. The umbrella term for a long thin head shape is referred to as dolichocephaly. Scaphocephaly is caused by the early fusion of the sagittal suture which runs from front to back at the top of the skull. Early fusion of a suture in infancy is called synostosis and this type is the most common form of craniosynostosis
  6. Scaphocephaly Causes: There are two types of the Scaphocephaly causes; first is during pregnancy and second is after delivery. In the most cases, the babies suffer from this skull complication when their position in pregnancy changes to a side. The head position is more important for the health and growth of a baby before as well as after delivery

Facts about Microcephaly CD

Causes: As a baby develops in the mother's uterus, the hand or foot starts out in the shape of a paddle. The paddle splits into separate fingers or toes. Craniosynostosis prevents the skull from growing normally, frequently giving the head a pointed appearance (acrocephaly). What is the treatment of polydactyly Symbrachydactyly causes. The cause of symbrachydactyly is unknown, but vascular dysgenesis during fetal development (subclavian artery supply disruption sequence) is a leading hypothesis 15). Based on this hypothesis, isolated transverse terminal limb deficiencies are associated with interruption of the subclavian artery distal to the. • Acrocephaly (or oxycephaly) results from fusion of the coronal suture plus any other suture, or fusion of all of the sutures. This causes the top of head to be pointed or conical. Acrocephaly is the most severe type of craniosynostosis. • Trigonocephaly results from fusion of the metopic suture, which causes a triangular shaped forehead Carpenter Syndrome is an exceptionally rare genetic diseases, with only around 300 confirmed cases in the United States. The disease reportedly affects one in a million people. We examine the cause

Megalencephaly (MEG) is a disorder characterized by an abnormally large brain.It is primarily a proliferative disorder of embryonic origin. It may involve all or part of the cerebral hemispheres and can be bilateral or unilateral.It is often associated with polymicrogyria or agyria See brain tumor disorders, NEUROFIBROMATOSIS, TRIGEMINAL ANGIOMATOSIS, TUBEROUS SCLEROSIS, PREMATURITY, HYDROCEPHALY, ACROCEPHALY, MACROCEPHALY, MICROCEPHALY, BIRTH ADJUSTMENTS.As the above classification indicates, many causes of mental retardation have been found. An estimated 50 to 60 per cent operate before birth, 8 per cent during birth. The Invitae Overgrowth and Macrocephaly Syndromes panel is intended to aid in the identification of a possible genetic cause for patients who present with a set of symptoms that include abnormal excessive height and/or weight and/or macrocephaly (>2 standard deviations). Onset may be prenatal or postnatal. Overgrowth may manifest in a symmetric. Personalized Cause, Inc. 835 E. Lamar Blvd. #246 Arlington, TX 76011. 1-765-325-575 Some of the most common signs of Carpenter syndrome include polydactyl digits or the presence of additional fingers or toes. Other common signs include webbing between the fingers and a pointed top of the head, also known as acrocephaly. Some people have impaired intelligence, but others with Carpenter syndrome are well within the normal range.

Human Polydactyly


  1. 2. A review of the literature reveals but one reference to scaphocephaly as a cause of dystocia. 3. Two of the varieties of craniostenosis, oxyeephaly and acrocephaly, should be extremely rare causes of dystocia, because (1) the diameters of the head are less than usual and (2) the fontanelles are open
  2. Apert syndrome is caused by one of two changes to the FGFR2 gene. This gene defect causes some of the bony sutures of the skull to close too early. This condition is called craniosynostosis. Treatment consists of surgery to correct abnormal bone growth of the skull, as well as for the fusion of the fingers and toes
  3. causes, types and approach to microcephaly and other congenital abnormalities of skull Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website
  4. Early coronal fusion causes acrocephaly or tower skull. Asymmetric fusions produce plagiocephaly. Collected by: Nahry O. Muhammad 36 37. 36. Somitomeres, paraxial mesoderm cranial to the somites, give rise to much of the skeletal muscle in the head EXCEPT: A. extrinsic muscles of the eye B. temporalis tongue muscles C. muscles of facial.
  5. Carpenter syndrome is a condition characterized by the premature fusion of certain skull bones (craniosynostosis), abnormalities of the fingers and toes, and other developmental problems. Craniosynostosis prevents the skull from growing normally, frequently giving the head a pointed appearance (acrocephaly)
  6. Craniosynostosis, the premature fusion of one or more sutures of the skull, is a common craniofacial anomaly, with an estimated incidence of 1/2000 to 1/3000 births.1,2 Characteristic deformities of skull shape occur as a result of different patterns of sutural fusion, while compensatory skull expansion occurs at unaffected sutures to accommodate the growing brain. Premature fusion of the.
  7. acrocephaly. pointed head. turricephaly. tower head, also called oxycephaly. trisomy 13. cutis aplasia is associated with what syndrome? Large amounts of blood caused by large cephalohematomas can cause what? resolution in about a week. What is the treatment for a cephalhematoma

Acrocephalosyndactyly, congenital malformation of the skeleton affecting the skull and limbs. The disorder most often is hereditary, but it may appear spontaneously. The head appears pointed (acrocephaly) because of premature closing of the cranial sutures between the individual bones that make u Acrocephaly or Turricephaly Kleeblattschädel Anomaly Cleft Lip and Cleft Palate Crouzon Syndrome Apert Syndrome. Apert syndrome is a form of acrocephalosyndactyly, a congenital disorder characterized by malformations of the skull, face, hands, and feet 16 Malformations and Deformities. Anomalies of the skeleton and soft tissues of the hand can be caused by congenital malformations or deformities acquired during growth. The most important malformations are associated with syndactyly, brachydactyly, oligodactyly, polydactyly, aphalangia, constriction rings, hypoplasia/aplasia of the thumb. Causes. There is some support that acrocephalosyndactyly occurs in an autosomal dominant mode. Evidence for this is that males and females are affected equally. Nonetheless, almost all cases are sporadic, signifying that most are attributable to fresh mutations or an environmental insult to the genome. Offspring of a parent with Apert syndrome. Acrocephaly. turricephaly (tall head) with the top of the skull assuming a cone shape . Adactyly. genetic condition that causes bone abnormalities (exostoses, short stature and cone-shaped ends of the long bones) and distinctive facial features (sparse scalp hair, rounded nose, long flat philtrum, and thin upper lip); caused by at least two.

General Information about Oxycephaly: Read morea about Oxycephaly general facts and information, covering statistics, prevalence, age profile, race, geography, and other overall information about the condition Acrocephaly: Acrocephaly occurs with combined premature fusion of the lambdoid, coronal, and sagittal sutures and can be seen in Crouzon and Apert syndromes. The anterior skull overgrows, causing. Saethre-Chotzen 7p21 AD craniosynostosis, acrocephaly, brachycephaly, flat facies, thin long pointed nose, cleft palate, cranial asymmetry, ptosis, malformed ears DiGeorge AD low-set ears, short ears, small mouth, submucous or overt palatal cleft, cleft lip, bulbous nose, square nasal tip, short philtrum, micrognathia, Velocardiofacia

Macrocephaly - Wikipedi

These less commonforms of synostosis include kleeblattschädel, or cloverleafdeformity, and acrocephaly, or oxycephaly (pointed head). Without earlyintervention,multisutural conditions often cause rising intracranial pressureand subsequent neurologic impairment What causes Lesch Nyhan syndrome? Lesch-Nyhan syndrome (LNS) is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). This deficiency occurs due to mutations in the HPRT1 gene located on the X chromosome Acrocephaly, also known as tower skull, results from combined sagittal, coronal, and lambdoid synostosis. The anterior cranium is elevated relative to the posterior cranium, causing the vault to slant from front to back. Acrocephaly is often seen in Crouzon or Apert syndromes. (See Craniosynostosis syndromes). Other deformitie Craniosynostosis is a medical term which literally means fused bones of the skull. The premature fusion of the cranial sutures cause the skull to grow abnormally. Depending on which sutures are involved, the skull, most commonly, will have either a short (front to back) cloverleaf shape (brachycephaly), or a pointed cone shape (acrocephaly)

FIL (also referred to as Congenital Infiltrating Lipomatosis of the Face or as Facial Infused Lipomatosis) is an ultra-rare craniofacial condition caused by a genetic mutation of the PIK3CA gene. The condition is typically visible at birth as the mutation causes an overgrowth affecting half of the face Bone disease, any of the diseases or injuries that affect human bones. Diseases and injuries of bones are major causes of abnormalities of the human skeletal system. Although physical injury, causing fracture, dominates over disease, fracture is but one of several common causes of bone disease, and disease is in fact a common cause of fracture The stenotic sutures are shown in blue. An extreme form of pansynostosis, skull growth occurs laterally, via the patent squamosal sutures (red arrows). Growth upward or forward in the midline through a length of suture or bony defect causes a focal bulge (green arrows). The 3 protrusions resemble a 3-leaf clover. (Contributed by Dr. Sherman Stein.

What is ACROCEPHALY? definition of ACROCEPHALY (Psychology

The breast develops along the mammary line/ridge, or the milk line. Which of the following is a possible site for acessory nipples or breasts 31. The most important region of the decidua for the nourishment of the conceptus is the decidua _____. A. frondosum B. capsularis C. parietalis D. is correct. The placenta is made of maternal tissue, the decidua basalis, and fetal tissue, the chorion frondosum or bushy/villous chorion. The smooth chorion or chorion laeve is covered by decidua capsularis, which disappears as the fetus grows. Codes from this chapter are not for use on maternal record

Macrocephaly or Big Head Department of Neurosurger

Waardenburg syndrome [] . Waardenburg syndrome (WS) is the most common cause of autosomal dominant syndromic hearing loss. It occurs in approximately 2 per 100,000 births and is estimated to account for 2% of all cases of congenital hearing loss in the United States ICD-10-CM Diagnosis Code Q75.0. Craniosynostosis. 2016 2017 2018 2019 2020 2021 Billable/Specific Code POA Exempt. Applicable To. Acrocephaly; Imperfect fusion of skul Search Page 1/1: craniopharyngioma. 7 result found: ICD-10-CM Diagnosis Code D44.4 [convert to ICD-9-CM] Neoplasm of uncertain behavior of craniopharyngeal duct. Craniopharyngioma; Neoplasm of uncertain behavior, pituitary gland or. ICD-10-CM Diagnosis Code D44.4

English Etymology. from Ancient Greek????? (makrós, long ) + ?????(kephal?, head ).Adjective. macrocephalic (comparative more macrocephalic, superlative most macrocephalic). Having an abnormally large or elongated head. 1873, John Wells Foster, Pre-Historic Races of the United States, Chicago: S.C. Griggs & Co., Chapter 9, p. 327, [1] In 1849, M. Rathke stated that artificially. excess accumulation of cerebrospinal fluid in the brain, when cerebrospinal fluid stops draining, multiple causes - 25% congenital but can be acquired (problematic in adults because skull has finished growing, in infants it can cause rapid expansion of the skull because skull is malleable), 50% mortality rate if not treated surgically (can stop spontaneously), only a few cases in. acrocephaly is a very common reason for refer-ral of infants to neurosurgical office practices. investigator (a pediatric neurosurgeon) to identify causes of macrocephaly and to search for subdural collections that may have been overlooked in the initial interpreta-tions. Macrocephaly was attributed to hydrocephalus i Carpenter syndrome is another manifestation of craniosynostosis, involving a pointed head (acrocephaly) and, severely, a cloverleaf skull. Typically, Carpenter syndrome involves cutaneous syndactyly between 2 or more fingers or toes, most commonly between the third and fourth fingers

Apert syndrome Genetic and Rare Diseases Information

Acrocephaly (Concept Id: C0030044

  1. Craniosynostosis prevents the skull from growing normally, frequently giving the head a pointed appearance (acrocephaly). Is having 6 fingers genetic? Polydactyly may be passed down in families. This trait involves only one gene that can cause several variations. African Americans, more than other ethnic groups, can inherit a 6th finger
  2. The syndrome causes physical overgrowth during the first years of a child's life. Children with the syndrome are many times taller and have larger heads than other children the same age. Due to the distinctive shape and size of their heads, Sotos syndrome is sometimes referred to as, 'cerebral gigantism.' There is a certain amount of irony in.
  3. suture defects - craniosynostosis - scaphocephaly (keel - sagittal), acrocephaly (tower - coronal), plagiocephaly (asymmetrical), metopic suture (fusion by 6 yrs. normally) Skeletal development - post-cranial axial skeleton: from sclerotome - vertebrae, ribs, & sternum endochondral ossification - hyaline cartilage model calcifie
  4. Neurulation Neural Tube. The nervous system develops when the notochord induces its overlying ectoderm to become neuroectoderm and to develop into the neural plate. The neural plate folds along its central axis to form a neural groove lined on each side by a neural fold. The two neural folds fuse together and pinch off to become the neural tube.Fusion of the neural folds begins in the middle.
  5. Abstract. We identified de novo nonsense variants in KIDINS220/ARMS in three unrelated patients with spastic paraplegia, intellectual disability, nystagmus, and obesity (SINO). KIDINS220 is an essential scaffold protein coordinating neurotrophin signal pathways in neurites and is spatially and temporally regulated in the brain

Carpenter Syndrome - NORD (National Organization for Rare

>> External Causes. Other Resources >> HCPCS Alpha >> Medical Dictionary >> Drug Directory . Tips Contribute. showing results 1 - 1: view: 756.0 Anomalies of skull and face bones. Absence of skull bones. Acrocephaly. Congenital deformity of forehead. Craniosynostosis. Crouzon's disease. Hypertelorism. Imperfect fusion of skull. Oxycephaly. NUTRITION & DISEASE. Iron and Cognitive Function. Iron deficiency (ID) is the single most significant nutrient deficiency, affecting 15% of the world population and causing anemia in 40% to 50% of children. Iron is essential for neurologic activity, including synthesis of dopamine, serotonin, and catecholamine and, possibly, formation of myelin MOMO syndrome is an extremely rare genetic disorder which belongs to the overgrowth syndromes and has been diagnosed in only four cases around the world. The name is an acronym of the four primary aspects of the disorder: M acrosomia (excessive birth weight), O besity, M acrocephaly (excessive head size) and O cular abnormalities Maxillary hypoplasia causes midface hypoplasia with reduced intraorbital volume and subsequent severe bilateral (or unilateral ) proptosis [1, 3, 5]. The latter can in turn cause extraocular muscle imbalance with squint and visual disturbances , besides other ocular defects and malformations in PS patients [3, 4, 15] acrocephalosyndactyly: [ ak″ro-sef″ah-lo″sin-dak´tĭ-le ] any of a group of autosomal dominant disorders in which craniostenosis is associated with acrocephaly (conical deformity of the head) and syndactyly ( webbed fingers and toes ), sometimes occurring with additional anomalies. Type I is Apert's syndrome ; type III is Chotzen's syndrome ;.

Oxycephaly - Wikipedi

  1. unilateral = anterior plagiocephaly: causes harlequin eye i.e. superior and lateral displacement of orbital ridge) bilateral = brachycephaly (no AP growth but wide and tall head) untreated can become Oxycephaly aka turricephaly i.e. tower skull short AP, narrow but tall (see acrocephaly) Metopic: 10% (trigonocephaly
  2. A. plagiocephaly B. craniostenosis C. acrocephaly D. scaphocephaly E. microcephaly: E. is correct. If the brain does not grow, neither will the skull. This results in microcephaly. Premature closure of cranial sutures is called craniostenosis. Early sagittal suture fusion causes scaphocephaly or a long skull
  3. Acrocephaly, adenomatous polyposis of the colon, disorders ofthe adrenal gland, adrenogenital syndrome, ALA dehydratase or ALA-D porphyrias,ALS, Alzheimer disease, anemias such as hereditary sideroblastic, sex-linkedhypochromic sideroblastic or familial splenic anemias and Angelman syndrome areall known genetic disorders
  4. Apert syndrome (AS), Online Mendelian Inheritance in Man (OMIM) 101200, is a rare genetic condition that was first described by Wheaton in 1894 and then by French pediatrician, Dr Eugene Charles Apert, who reported a summary on nine cases in 1906 [].It presents with craniosynostosis (premature fusion of the cranial sutures) and acrocephaly, including brachycephaly, midfacial hypoplasia, and.
  5. ant genetic insults. There are nearly 180 identified syndromes and, to date, over 60 single gene mutations are identified as causal

Megalencephaly Radiology Reference Article Radiopaedia

Chapter 65 Methods of Cranial Vault Reconstruction for Craniosynostosis Jose Hinojosa Cranial sutures are essential components in the development of the skull. Nonfunctional sutures during the evolution of the cranial vault and the skull base lead to evolving deformities that may end in neurologic sequel. Although the term craniosynostosis was first used by Bertolotti i dentofacial anomalies (524.0-524.9) nonteratogenic deformity of chest wall (754.81-754.89) lipochondrodystrophy [Hurler's syndrome] (277.5) Morquio's disease (277.5) 756.8 Other specified anomalies of muscle, tendon, fascia, and connective tissue. 756.9 Other and unspecified anomalies of musculoskeletal system Oxycephaly definition, a malformation in which the head is somewhat pointed, caused by premature closure of the skull sutures. See more causes the top of the skull to be pointed or cone-shaped. It is caused by a premature fusing of the coronal and sagittal sutures. Also known as turricephaly or high-head syndrome.14 Pierre Robin syndrome: A birth defect characterized by abnormalities in the facial bones, resulting in a smaller than normal lower jaw or receding chin

ICD-10-BE. Congenital malformations, deformations and chromosomal abnormalities ( Q00-Q99) Note (*): Codes from this chapter are not for use on maternal records. Excludes2: inborn errors of metabolism ( E70-E88) Congenital malformations and deformations of the musculoskeletal system ( Q65-Q79) Q75. Other congenital malformations of skull and. causes the top of the skull to be pointed or cone- shaped. It is caused by a premature fusing of the coronal and sagittal sutures. Also known as turricephaly or high- head syndrome. 7 • Pierre Robin syndrome: A birth defect characterized by abnormalities in the facial bones, resulting in a smaller than normal lower jaw or receding chin ox·y·ceph·a·ly (ŏk′sē-sĕf′ə-lē) n. pl. ox·y·ceph·a·lies A congenital abnormality of the skull in which the top of the head assumes a conical or pointed shape. Also called acrocephaly. [From Greek oxukephalos, sharp-headed : oxus, sharp; see oxygen + -kephalos, -cephalous.] ox′y·ce·phal′ic (-sə-făl′ĭk), ox′y·ceph′a·lous. Due to bicoronal craniosynostosis, there is brachycephaly and acrocephaly, resulting in a strawberry-shaped head. In other words, one can detect an abnormal skull with a flat occiput, high forehead, midfacial hypoplasia (flat face), hypertelorism of the eyes and eyelid edema by a combination of conventional 2D imaging with 3D maximum mode (for.

Apert Syndrome - NORD (National Organization for Rare

Synonyms for Apert syndrome in Free Thesaurus. Antonyms for Apert syndrome. 1 synonym for acrocephaly: oxycephaly. What are synonyms for Apert syndrome Search 2021 ICD-10 codes. Lookup any ICD-10 diagnosis and procedure codes Pfeiffer syndrome is an autosomal dominant disorder (Pfeiffer, 1964; Saldino et al., 1972).Cohen (1993) stated that 7 Pfeiffer syndrome pedigrees (three 3-generation and four 2-generation) had been reported, in addition to at least a dozen sporadic cases. In a study of sporadic cases of Crouzon syndrome and Pfeiffer syndrome, Glaser et al. (2000) used 4 intragenic polymorphisms to screen a.

Chp 3Saethre–Chotzen syndrome - Wikipedia

Acrocephaly & Coombs Negative Hemolytic Anemia: Causes

Altunhan et al. (2011) described a Turkish boy who was born with acrocephaly and a peculiar facies characterized by frontal bossing. Digital abnormalities included clinodactyly of the fifth fingers, membranous syndactyly of fingers 3 and 4, syndactyly of toes 1 and 2, and preaxial polydactyly of the big toes bilaterally Q75.0 is a valid billable ICD-10 diagnosis code for Craniosynostosis . It is found in the 2021 version of the ICD-10 Clinical Modification (CM) and can be used in all HIPAA-covered transactions from Oct 01, 2020 - Sep 30, 2021 . POA Exempt Oxycephaly / Acrocephaly / Turricephaly-pointed head-all sutures prematurely close 7. Triphyllocephaly/K of all sutures except squamosal CONGENITAL DISEASES OF THE BRAIN 1. Dysgenesis - defective development with no disturbance of neural tube closure Holoprosencephaly - failure of cleavage between the 2 cerebral hemispheres; partially or. Synonyms for Birth defects in Free Thesaurus. Antonyms for Birth defects. 4 synonyms for congenital disorder: birth defect, congenital abnormality, congenital anomaly, congenital defect. What are synonyms for Birth defects

Acrocephaly (Oxycephaly): Symptoms, Diagnosis and

Saethre-Chotzen syndrome (SCS), also known as acrocephalosyndactyly type III, is a rare congenital disorder associated with craniosynostosis (premature closure of one or more of the sutures between the bones of the skull).This affects the shape of the head and face, resulting in a cone-shaped head and an asymmetrical face. Individuals with SCS also have droopy eyelids (ptosis), widely spaced.

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